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Valeriana PANTEA et al; INVESTIGATION OF THE EFFECTS OF COPPER-COORDINATED THIOSEMICARBAZONE COMPLEXES ON NITRIC OXIDE METABOLITE PARAMETERS IN ERYTHROCYTES IN VIVO
Introduction: Copper-coordinated complexes (CCCs) are considered promising antitumor agents with customizable pharmacological properties and potential as safer, cost-effective alternatives to conventional chemotherapy. Nitric oxide (NO) is central to vascular and immune regulation. This study evaluated the effects of copper-coordinated thiosemicarbazone complexes (CCTs) on NO metabolite levels in vivo.
Materials and Methods: A total of 120 rats were divided into 10 groups, each with male and female subgroups. Experimental groups received various CCTs (10 µg/kg, subcutaneously, 30 days); controls received saline. NO metabolites (peroxynitrite/nitrate and nitrite) were measured in erythrocytes.
Results: All CCTs induced non-significant changes in peroxynitrite/nitrate levels, except TIA-160 in males, which showed a slight 15% diminish versus controls. Nitrite levels decreased in males (except CMA-18) and showed a non-significant enhance in females. The NO metabolite ratio generally lowered, except for a 3–11% elevation in certain female subgroups. Overall, CCTs showed moderate to minimal effects on oxidative/nitrosative stress, with sex-dependent trends.
Conclusion: CCTs exert sex-dependent, moderate effects on NO metabolism in erythrocytes, supporting their potential as anti-inflammatory or immunosuppressive agents.
Keywords: copper coordination compounds, thiosemicarbazones, erythrocytes, nitric oxide metabolism