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Abstract_AntonFICAI

Considering the very high need of bone grafts, about 49% of the total market share of the grafting materials, many researchers focused their efforts in developing new and improved grafting materials: metals and alloys (firsts generation of biomaterials), ceramics and polymers (second generation of biomaterials), composites and nanocomposites (third generation of biomaterials) but also tissue engineered grafts (fourth generation of biomaterials). In the development of all these materials, researchers tried to design materials with improved or even new properties by compositional and morpho-structural design having in mind pure regenerative purposes or even the treatment of bone-specific diseases including infections, cancer, osteoporosis, etc. Since the very beginning, porous or dense materials were developed, in many cases biomimetic approaches were considered but also, starting from the second generation of biomaterials the circularity and green synthesis were more and more used in developing grafting materials. Currently, many researchers are trying to develop materials by exploiting the benefits of the additive manufacturing methods.

Acknowledgements:

This research was funded by UEFISCDI through the project “Nanostructured Bone Grafts with Predetermined Properties- CollNanoBone” project number 29ROMD/20.05.2024.