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Abstract_Huaqiong LI

Tissue injury and repair has always been a cutting-edge scientific issue in the world. The tissue regeneration and repair barriers after damage seriously endanger human life and health. In order to solve the key problems of transplant-induced immune rejection, insufficient mechanical support, and poor biological functions in the process of tissue injury and repair, our research team has developed dECM (decellularized extracellular matrix) based composite hydrogels for tissue defect repair. Through constructing tissue engineered composite biomaterials, we can modulate tissue regeneration with an optimized microenvironment (such as multi-scale physical signal stimulation and biochemical signals), and precisely regulate the biological behavior of cells in the tissue injury site, thereby achieving regeneration and repair of damaged tissues (such as intervertebral discs, bone, cartilage, wound, etc.).