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Abstract Ali IMRAN

Advanced therapeutic approaches are desperately required due to the limitations of traditional chemotherapy, like systemic toxicity, poor absorption, and non-specific targeting. An encouraging platform for addressing these challenges is the development of nano-anticancer medications. This method uses nanomaterials, including liposomes, dendrimers, polymeric nanocarriers, and metallic nanoparticles, to encapsulate or anchor the organic molecules. The improved solubility, controlled and targeted drug release, and better tumor tissue targeting via active and passive processes are features of the new generation nano- anticancer drugs. These nano-drugs aggregate precisely in tumour tissues and decrease harm to healthy cells through better permeability and retention effect and ligand-mediated recognition. Also, new developments in stimuli-responsive nanoparticles and nanodrug conjugates increase the precision and efficacy of the treatment. With a stress on the significance as a game-changing treatment in contemporary oncology, this presentation will cover the current needs, developments, clinical translation challenges, mechanism of action, and prospects for the future of nano-anticancer drugs. Besides, the preparation and application of these smart nano-medicines may be safe, more effective, and patient-friendly cancer treatments.

Keywords: Cancer, Chemotherapy, Nano anticancer drugs, Mechanism of action, future perspectives.