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Melike SURMELİ, Muhammet Fatih UCAR, Eda Ayca ARI, Busra OKTAY, Ayse Betul BİNGOL, Fatih CİFTCİ, Ilkay SENEL, Cem Bulent USTUNDAG; Productıon of an Antıbacterıal Wound Dressıng Contaınıng PVA and Saussurea Costus Extract for Post-Surgıcal Incısıons
Postoperative incision sites are particularly defenseless to inflammatory reactions, which can significantly hinder the healing cascade and elevate the risk of postoperative complications. While traditional topical formulations, such as ointments and creams, afford essential antimicrobial protection, their application frequently causes patient discomfort. In contrast, wound dressings have appeared as effective alternatives, providing both the constant delivery of therapeutic agents and strong physical protection for the wound environment. Recent research has increasingly focused on developing advanced wound dressings that include naturally derived bioactive compounds. These next-generation wound dressings offer a sophisticated, multifaceted strategy for wound care by mutually combining antimicrobial and anti-inflammatory properties with the structural advantages inherent to biocompatible polymer matrices. In the current investigation, a novel antibacterial wound dressing was fabricated through the incorporation of Saussurea costus (S. costus) extract – respected for its anti-inflammatory and antimicrobial effectiveness – into a nanofibrous scaffold. This scaffold was composed of polyvinyl alcohol (PVA) and produced via the electrospinning method. PVA was chosen as the primary polymer due to its environmental degradability, fundamental flexibility, and excellent moisture-retention capacity. A comprehensive characterization of the engineered dressing was conducted, encompassing detailed morphological, chemical, mechanical, and antibacterial assessments. The resulting nanofibers exhibited a high surface area and a porous architecture, highlights highly conducive to cellular activity, gas exchange, and moisture regulation. All at once, the material demonstrated creditable mechanical integrity and strong antimicrobial performance. These findings firmly highlight the potential of the PVA/S. costus composite system as a biocompatible, cost-effective, and innovative solution for wound care, effectively mitigating several limitations associated with current conventional treatment models.
Keywords: Electrospinning, extraction, nanofiber, Saussurea Costus, wound dressing