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Abstract_Silvia CERE

Magnesium alloys offer potential advantages as degradable biomaterials for osteosynthesis, because they provide good biocompatibility and high primary stability. The main advantage of these alloys is their ability to biodegrade; however, their high corrosion rate in physiological environments and the formation of hydrogen gas as a corrosion product limit their application.

The surface modification of these materials can be considered a tool to protect the metal and, in turn, create a bioactive surface for osseointegration. Metal degradation is expected to accompany bone tissue formation and maintain its mechanical properties until its function is fulfilled. The corrosion rate of Mg alloys can potentially be controlled by changes in metallurgy, microstructure, and surface treatments. It is also expected that the layers could generate a bioactive barrier. The chemical, morphological, electrochemical, and topological characteristics of AZ91 alloy samples are analyzed, with and without surface modification, at different immersion times in simulated physiological solution. Results are also presented in an in vivo model in Wistar rats implanted at 7, 15, 30 days and 6 months and the histomorphological characteristics of the new bone around the implants and their possible systemic effects are described.