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Abstract_Miguel A. Mateos Timoneda
Printability in 3D extrusion bioprinting encompasses extrudability, filament formation, and shape fidelity[i]. Rheological properties can predict the shape fidelity of printed hydrogels. In this talk, we will explore the effect of different parameters on tan(δ), and therefore the printability of methylcellulose (MC) hydrogels[ii]. After, I will show how these results will help in the further development of more complex bioinks and structures, which can give rise to novel constructs for uses as 3D models and scaffolds for Tissue Engineering and Regenerative Medicine, using coaxial bioprinting. I will explain the development of a Do-It-Yourself (DIY) coaxial bioprinter and its validation using a well-know bioink[iii]. Furthermore, an example will be given on the use of self-assembled peptides as bioink.
[i] M Jergitsch, MA Mateos-Timoneda. 3D extrusion bioprinting: rational bioink design and advanced fabrication techniques. Trends Biotechnol. In press (2025). https://doi.org/10.1016/j.tibtech.2025.06.008
[ii] M Jergitsch, Z Alluè-Mengual, RA Perez, MA Mateos-Timoneda. A systematic approach to improve printability and cell viability of methylcellulose-based bioinks. Int. J. Biol. Macromol. 253(7), 127461 (2023). https://doi.org/10.1016/j.ijbiomac.2023.127461
[iii] M Jergitsch, R Soiunov, F Selinger, M Frauenlob, LM Delgado, S Perez-Amodio, RA Perez, MA Mateos-Timoneda. Fabrication and validation of an affordable DIY coaxial 3D extrusion bioprinter. Sci Rep 15, 22978 (2025). https://doi.org/10.1038/s41598-025-06478-9